HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → HCID 178451387, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | benzhydryl (6R,7R)-3-(bromomethyl)-7-[[(2Z)-2-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethoxy]imino-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | HCID 172953016 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 178451387 | HCID 178451387 | 68% |
Reaction Steps
A solution of triphenylphosphine (0.524 g) and diphenylmethyl (6R,7R)-3-bromomethyl-7-[(Z)-2-(t-butoxycarbonylmethoxyimino)-2-(2-tritylaminothiazol-4-yl)acetamido]ceph-3-em-4-carboxylate (0.985 g) [prepared according to the method of UK Patent Specification No. 2036738A] in ethyl acetate (10 ml) was stirred at ambient temperature for 16 hr. During this time, a solid was deposited. This was filtered off, washed with ethyl acetate, and dried in vacuo to give the title compound (0.848 g); νmax (CHBr3) 3385, 3280 (NH), 1790 (β-lactam), 1728, 1720 (ester), 1680, 1522 cm-1 (amide).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04666899 |
| Source dataset | uspto-grants-1987_05 |
| ORD ID | ord-e47710765f51462da5049d93c923ae6b |
| Source note | uspto-grants-1987_05 |