Hydrochloric Acid → HCID 178442412, compound

Participants

Reaction Steps

A stirred solution of the product of stage (d) in formic acid (0.8 ml) was treated with 11M hydrochloric acid (56 μl). After 2.5 h the reaction mixture was filtered and the filtrate was added dropwise to vigorously stirred ether (50 ml). The precipitated solid was collected by filtration, washed with ether and dried in vacuo to give the title compound as a solid (78 mg); νmax (Nujol) 3280 (--NH), 2200 (C≡C), 1776 (β-lactam); τ(DMSO-d6) values include 0.27 (NH), 3.24 (--CH=CH--C≡C), 4.24 (--CH=CH--C≡C), 4.17 (7H), 4.72 (6H), 5.28 (OCH2CO2H), 7.68 (C≡C--CH2) and 8.86 (C≡C--CH2CH3).

Provenance & Evidence