N-(2-Phenylacetyl)-L-aspartic acid → HCID 54081971, compound

Participants

Reaction Steps

After cooling to 0°-5° C. and filtration the reaction mixture was dried to obtain N-phenyl acetylaspartic acid (120 g), 99.77% titer. 78 g of N-phenylacetyl aspartic acid were suspended in 80 ml of acetic anidride. The mixture was heated to 80° for 2 hours. 70 g of N-phenylacetyl aspartic anhydride were obtained after cooling and insolubilization with a solvent. 52 g of N-phenylacetyl aspartic anhydride suspended in 52 ml of glacial acetic acid and 100 ml of dichloroethane cooled to 10° C. were added with 200 ml of dichloroethane containing 40.2 g of phenylalanine methyl ester.

Provenance & Evidence