HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 3-Chloro-1-methyl-1,2-dihydroquinoxalin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1-Methyl-1,4-dihydro-2,3-quinoxalinedione | HCID 600627 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-Chloro-1-methyl-1,2-dihydroquinoxalin-2-one | HCID 1471088 | — |
Reaction Steps
A mixture of 56.1 g. (0.32 m.) of 1,4-dihydro-1-methylquinoxalin-2,3-dione, 10 ml. of DMF, 50 ml. (0.67 m.) of thionyl chloride and 1 l. of toluene was refluxed for 1 hour, cooled, and stripped, finally under high vacuum to a crude dark solid, m.p. 124°-130° C. of sufficient purity to use in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04668678 |
| Source dataset | uspto-grants-1987_05 |
| ORD ID | ord-09d9ee2c8d7d469888f7ac08171b223c |
| Source note | uspto-grants-1987_05 |