Dicyclohexylcarbodiimide → HCID 14792152, compound

Participants

Reaction Steps

4-Amino-1-(6,7-dimethoxyquinazolin-4-yl)piperidine (0.9 g) was added to a mixture of Boc-L-valine (1.3 g), N,N'-dicyclohexylcarbodiimide (0.7 g) and acetonitrile (30 ml) while cooling with ice. The mixture was further stirred at room temperature for 30 minutes. Insoluble substances were removed from the reaction solution by filtration. The filtrate was concentrated and partitioned between ethyl acetate and a saturated aqueous solution of NaHCO3. The organic layer was dried over anhydrous magnesium sulfate and concentrated. By purification using a 40 g silica gel column, 4(Boc-L-valyl)amino-1-(6,7-dimethoxyquinazolin-4-yl)piperidine (1 g, 74%) was obtained.

Provenance & Evidence