Hydrochloric Acid → 1-[Bis(hydroxymethyl)-methyl]-2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

Participants

Reaction Steps

To 0.0125 mole (3.33 g) of 1-[bis(hydroxymethyl)-methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 15 ml of a 37% aqueous formaldehyde solution and 15 ml of 99% formic acid are added. The reaction mixture is then kept at 100° C. for 10 hours. After cooling 50 ml of a 15% aqueous hydrochloric acid solution are added to the reaction mixture, which is then evaporated under reduced pressure. After thoroughly dehydrating the reaction mixture it is triturated with a small amount of acetone to yield the aimed compound with a melting point of 199° to 201° C. (ethanol/ether).

Provenance & Evidence