Benzoyl chloride → HCID 13701395, compound

Participants

Reaction Steps

0.01 mole (2.7 g) of 1-[bis(hydroxymethyl)-methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline is dissolved in 50 ml of benzene under slight warming, and the solution obtained is admixed with a solution of 0.015 mole (0.6 g) of sodium hydroxide in 10 ml of water. 0.011 mole (1.5 g) of benzoyl chloride is added dropwise to the reaction mixture under cooling and stirring. When the addition is complete, the reaction mixture is stirred at room temperature for an additional hour, the organic phase is separated, and the aqueous phase is extracted twice with chloroform. The organic phases are combined, dried and evaporated to yield the aimed compound with a melting point of 161° to 163° C. (methanol/ether).

Provenance & Evidence