HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 13885352, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Chlorobenzaldehyde | HCID 6996 | — |
| Reactant | 2-Pyrrolidone | HCID 12025 | — |
| Reactant | 1-(2-Pyrimidinyl)piperazine | HCID 88747 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 13885352 | HCID 13885352 | 87% |
Reaction Steps
A solution of 2-pyrrolidinone (4.25 g, 0.05 mole), 1-(pyrimidin-2-yl)piperazine (8.2 g, 0.05 mole) and 2-chlorobenzaldehyde (7.05 g, 0.05 mole) in 200 mL toluene was stirred and heated for 16 hour with an attached Dean-Stark trap for azeotropic removal of water. The solution was concentrated in vacuo to provide 16.2 g, (87%) of product. Recrystallization from ethanol gave white crystals, m.p. 166°-177°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04668687 |
| Source dataset | uspto-grants-1987_05 |
| ORD ID | ord-d04b3d9f5b5a420e806996225d091be6 |
| Source note | uspto-grants-1987_05 |