Ethanol → HCID 135626413, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3.15 g (9.6 mmol) of 2-(2,5-dimethoxyphenylacetylamino)5-methylbenzoic acid (m.p. 163° to 164.5° C.) obtainble by the same method as in Synthesis example 2 and 0.90 g (20ml) of formamide were heated at 160° C. for 3 hours. After cooling, the solidified residue was added to a mixed solution of ethanol (100 ml) and acetone (100 ml) and dissolved therein by heating. After cooling, the precipitated crystals were collected by filtration to obtain 1.45 g (yield 49 %) of 2-(2,5-dimethoxyphenylmethyl)-6-methyl-4(3H)-quinazolinone.

Provenance & Evidence