N,N-Dimethylethylenediamine → HCID 13646219, compound

Participants

Reaction Steps

A mixture of 295 mg (1 mmol) of 2-{2-(4-methoxyphenyl)ethyl}-4H-3,1-benzoxazin-4-one synthesized in the same manner as in Synthesis example 2 and 88 mg (1 mmol) of 2-dimethylaminoethylamine in xylene (5 ml) was heated under reflux for 2 hours. After the xylene was distilled off under reduced pressure, the crude crystals obtained were purified by silica gel column chromatography (eluent; 3% methanol/methylene chloride) to obtain 260 mg (76%) of 3-(2-dimethylaminoethyl)-2-{2-(4-methoxyphenyl)ethyl}- 4(3H)-quinazolinone.

Provenance & Evidence