Hydrochloric Acid → Ethyl 5-hydroxy-7-(2-methylphenyl)-1-oxo-1,3,4,7-tetrahydrobenzo[c]furan-6-carboxylate

Participants

Reaction Steps

50 mmol of 2-methylbenzaldehyde, 50 mmol of ethyl 3-butylaminocrotonate and 50 mmol of ethyl 4-acetoxy-3-oxobutanecarboxylate together with 100 ml of ethanol were boiled under reflux overnight, then 10 ml of concentrated HCl and 20 ml of water were added, and the mixture was boiled for a further hour. The product is recrystallized from ethanol.

Provenance & Evidence