HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-(Chloromethyl)-2-[(4-chlorophenyl)methyl]-2-phenyl-1,3-dioxolane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 3-Chloro-1,2-propanediol | HCID 7290 | — |
| Reactant | Ethanone, 2-(4-chlorophenyl)-1-phenyl- | HCID 95829 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-(Chloromethyl)-2-[(4-chlorophenyl)methyl]-2-phenyl-1,3-dioxolane | HCID 13264211 | 98% |
Reaction Steps
69 g (0.3 mol) of phenyl 4-chlorophenylmethyl ketone, 66.3 g (0.6 mol) of 3-chloropropane-1,2-diol and 5.2 g (0.03 mol) of p-toluenesulphonic acid in 600 ml of toluene are refluxed for three days in a water separator. The reaction mixture, when it is cold, is extracted with sodium bicarbonate solution, dried over sodium sulphate and evaporated down in vacuo. 95 g (98% of theory) of 4-chloromethyl-2-(4-chlorophenylmethyl)-2-phenyl-1,3-dioxolane of melting point 65° C. are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04668700 |
| Source dataset | uspto-grants-1987_05 |
| ORD ID | ord-44a64784046645b79dd207cb255a6265 |
| Source note | uspto-grants-1987_05 |