Ethyl benzoylacetate → HCID 20200616, compound

Participants

Reaction Steps

A stirred solution of sodium ethoxide (from 0.53 g. sodium) in ethanol (80 ml.) was treated with ethyl benzoylacetate (4.42 g.). After 1 hour, -(o-chloromethylphenyl)propyl chloride (4.57 g.) was added and stirring was continued for 24 hours. The mixture was then diluted with ether (100 ml.) and water (100 ml.). The organic layer was separated, washed with saturated brine (50 ml.), dried (MgSO4) and evaporated to give ethyl 2-benzoyl-3-(o-(3-chloropropyl)phenyl]propanoate (A) as a yellow oil (7.66 g.), NMR: 1.1 (3H,t), 2.1 (2H,m), 2.7-3.7 (6H,m), 4.1 (2H,m), 4.65 (1H,t) and 7.0-8.2 (9H,m)ppm, which was used without further purification.

Provenance & Evidence