Acetic Anhydride → HCID 322651, compound

Participants

Reaction Steps

Following the method of W. Steglich, et al., Liebigs, Ann. Chem., 1753, 1974, (21.0 gm) of glutamic acid in 75 ml of acetic anhydride, 150 mg of 4-dimethylamino-pyridine, and 75 ml of triethylamine was heated 60° C. overnight. The reaction mixture was then concentrated in vacuo, the residue taken up in dichloromethane and washed with water. The organic portion was treated with charcoal, filtered, concentrated and 1,5-diacetyl-2-pyrroidone was obtained crystalline from ether-dichloromethane, mp 62° C. 'H NMR (δ CDCl3): 1.8-2.8 (m, CH2), 2.3 (s, 3H, CH3), 2.55 (s, 3H, CH3), 4.8-5.0 ppm (dd, 1H, CHN).

Provenance & Evidence