Acetyl chloride → HCID 13922899, compound

HRID 979559Notes

Reaction equation

HRID 979559 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].O[C:6]1[CH:18]=[CH:17][C:9]2[S:10][C:11]([S:13](=[O:16])(=[O:15])[NH2:14])=[CH:12][C:8]=2[CH:7]=1>>[OH:3][C:1]1[C:9]2[S:10][C:11]([S:13](=[O:16])(=[O:15])[NH2:14])=[CH:12][C:8]=2[CH:7]=[CH:6][CH:2]=1.[OH:3][C:1]1[C:8]2[CH:12]=[C:11]([S:13](=[O:16])(=[O:15])[NH2:14])[S:10][C:9]=2[CH:17]=[CH:18][CH:2]=1

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 13922842HCID 13922842, compound

Product 2

HCID 13922899HCID 13922899, compoundHCID 13922901HCID 13922901, compound

Procedure

Employing the procedure substantially as described in Example 6, but using as the acylating agent acetyl chloride as used therein or an approximately equimolar amount of the acid chlorides described in Table III and substituting for the 5-hydroxy-2-sulfamoylbenzo[b]thiophene used therein an equimolar amount of 7-hydroxy-2-sulfamoylbenzo[b]thiophene or 4-hydroxy-2-sulfamoylbenzo[b]thiophene there are produced the acyloxy-2-sulfamoylbenzo[b]thiophenes also described in Table III in accordance with the following reaction scheme.

Sources & evidence

ORD record
ord-144b17d9685c46c7aaef26c7517218f5
Source dataset
uspto-grants-1987_05
Patent number
US04668697

Reaction notes

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