Acetic Acid → 5447-37-0

HRID 979581Notes

Reaction equation

HRID 979581 reaction equation
O=[CH:2][C:3]1[CH:11]=[CH:10][C:8]([OH:9])=[C:5]([O:6][CH3:7])[CH:4]=1.[S:12]1[CH2:18][C:16](=[O:17])[NH:15][C:13]1=[S:14].C([O-])(=O)C.[Na+].C(O)(=O)C>O>[OH:9][C:8]1[CH:10]=[CH:11][C:3]([CH:2]=[C:18]2[S:12][C:13](=[S:14])[NH:15][C:16]2=[O:17])=[CH:4][C:5]=1[O:6][CH3:7]

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 1183VanillinHCID 517045Sodium AcetateHCID 1201546Rhodanine

Product 1

HCID 28316035447-37-0

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of vanillin (30.4 g, 0.2 mol), rhodanine (26.6 g, 0.2 mol), anhydrous sodium acetate (41 g, 0.5 mol) and glacial acetic acid was stirred and heated at reflux for one and one-half hours. The cooled reaction mixture was added to water (1200 mL) and the yellow-orange solid that separated was collected, washed with water and air dried; yield 46 g.

Workup

  1. temperatureheated
  2. temperatureat reflux for one and one-half hours
  3. customThe cooled reaction mixture
  4. customthe yellow-orange solid that separated
  5. customwas collected
  6. washwashed with water and air
  7. customdried

Sources & evidence

ORD record
ord-ee2cdc6a4307452f8802f96f29499512
Source dataset
uspto-grants-1987_05
Patent number
US04668697

Reaction notes

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