Water → HCID 13922896, compound

Participants

Reaction Steps

To a solution of 5-[2-(dimethylamino)ethylthiomethyl]-2-sulfamoylbenzo[b]thiophene (2.34 g, 0.0064 mol) in 20 ml of water at 40-45° C. was added potassium peroxymonosulfate, "oxone", (5.93 g, 0.0096 mol). The mixture was stirred at room temperature over night and heated on the steam bath for 2 1/2 hours. The mixture was cooled and basified with NaHCO3. Filtration gave 2.5 g of crude product. Purification by silica gel chromatography eluting with 10% (V/V) methanol/CHCl3 gave 0.78 g of pale pink solid, m.p. 185.5-187° C., dec. (Yield 34%).

Provenance & Evidence