HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → [2-[(3-Amino-2-pyridinyl)[3-(dimethylamino)propyl]amino]phenyl]phenylmethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-(Dimethylamino)propyl chloride hydrochloride | HCID 94308 | — |
| Reactant | {2-[(3-Aminopyridin-2-yl)amino]phenyl}(phenyl)methanone | HCID 15586652 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | [2-[(3-Amino-2-pyridinyl)[3-(dimethylamino)propyl]amino]phenyl]phenylmethanone | HCID 53769600 | — |
Reaction Steps
To a stirred suspension of sodium hydride (in mineral oil) in anhydrous dimethylformamide, under nitrogen atmosphere was added, portionwise, [2-[(3-amino-2-pyridinyl)amino]phenyl]phenylmethanone. To the mixture was added 3-dimethylaminopropyl chloride hydrochloride to give a solution containing some of the title compound as indicated by chemical ionization mass spectrascopy analysis. With time, this cyclized spontaneously to the corresponding pyrido[2,3-b][1,4]benzodiazepine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04668675 |
| Source dataset | uspto-grants-1987_05 |
| ORD ID | ord-721d65cf4fdd45e6b595202b60618f6e |
| Source note | uspto-grants-1987_05 |