HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 22222887, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Methyl 4-(bromomethyl)benzoate | HCID 256687 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Product | HCID 22222887 | HCID 22222887 | — |
Reaction Steps
To a stirred suspension of 1.11 grams of hydroxylamine hydrochloride and 6.78 grams of anhydrous sodium carbonate in 20 ml of dry N,N-dimethylformamide (DMF) is added a solution of 7.49 grams of p-methoxycarbonylbenzyl bromide in 30 ml of dry DMF. The mixture is stirred at ambient temperature for 24 hours. Insoluble material present is removed by filtration and the filtrate is concentrated. The above-named product is obtained from the resulting residue by preparative liquid chromatography as 2.8 grams of a white solid, melting at 129°-131° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04668727 |
| Source dataset | uspto-grants-1987_05 |
| ORD ID | ord-f706b8a7c8f24ebea7d77960e4946bfe |
| Source note | uspto-grants-1987_05 |