2-Amino-4-methoxy-6-methyl-1,3,5-triazine → HCID 13729507, compound

HRID 979665Notes

Reaction equation

HRID 979665 reaction equation
[F:1][CH:2]([F:19])[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[S:10]([N:13](CC)[C:14](=[O:16])[O-])(=[O:12])=[O:11].[NH2:20][C:21]1[N:26]=[C:25]([O:27][CH3:28])[N:24]=[C:23]([CH3:29])[N:22]=1>ClC1C=CC=CC=1>[F:19][CH:2]([F:1])[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[S:10]([NH:13][C:14]([NH:20][C:21]1[N:26]=[C:25]([O:27][CH3:28])[N:24]=[C:23]([CH3:29])[N:22]=1)=[O:16])(=[O:11])=[O:12]

Participants

4

Reactant 2

HCID 154662-Amino-4-methoxy-6-methyl-1,3,5-triazineHCID 86741548HCID 86741548, compound

Product 1

HCID 13729507HCID 13729507, compound

Reagents, catalysts & solvents 1

HCID 7964ChlorobenzeneSolvent

Procedure

A solution of 1.48 g of N-(2-difluoromethoxy-phenylsulfonyl)-ethylcarbamate and 0.62 g of 2-amino-4-methoxy6-methyl-1,3,5-triazine in 20 ml of chlorobenzene is refluxed. After concentration of the yellow solution by evaporation, and chromatographical purification of the residue, there is obtained a colourless oil which crystallises from an acetone/diethyl ether mixture by the addition of hexane. The yield is 0.45 g (23.1% of theory) of N-(2-difluoromethoxyphenylysulfonyl)-N'-(4-methoxy-6-methyl-1,3,5-triazin-2-yl)-urea, m.p. 140°-141° C.

Workup

  1. customAfter concentration of the yellow solution by evaporation, and chromatographical purification of the residue
  2. customthere is obtained a colourless oil which
  3. customcrystallises from an acetone/diethyl ether mixture by the addition of hexane

Sources & evidence

ORD record
ord-c946fd86d10443698ed89472a2163600
Source dataset
uspto-grants-1987_05
Patent number
US04668800

Reaction notes

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