Epichlorohydrin → HCID 13371497, compound

Participants

Reaction Conditions

Reaction Steps

In a flask, the mixture of 35 g of 2-carbethoxy 4-(5-methyl-2-thiophene carboxamido)phenol and 175 ml of epichlorohydrin, is heated to 110° C., then 2.9 g of benzyltrimethylammonium chloride are introduced. The reaction mixture is then heated to reflux for 30 mins., then cooled. Once the temperature of the medium has dropped again to 50° C., 200 ml of water are added and the mixture is stirred strongly. After decantation, the aqueous phase is extracted twice with ether and the organic phases are dried over magnesium sulfate, filtered and concentrated in vacuo. The residue hardens in ether. After three washings in 50 ml of isopropylic ether, 30 g of 1-[2-carbethoxy 4-(5-methyl 2-thiophene carboxamido)phenoxy]2,3-epoxy propane are obtained in the form of white crystals melting at 109° C.

Provenance & Evidence