Epichlorohydrin → HCID 13370622, compound

Participants

Reaction Steps

To a solution of 50% aqueous DMSO (280 ml), containing sodium hydroxide (5.60 g, 140 mmol) was added 7-hydroxy 2,3,-diphenylchromone (44.01 g, 140 mmol) and the resultant mixture was stirred until most of the solid went into the solution. Epichlorohydrin was then introduced into the suspension. The solution was stirred at room temperature (RT) for 2.5 days and solid formed during the reaction was collected from time to time (about twice a day). The white solid (total=47.58 g) was recrystallized from isopropyl alcohol several times to afford 28.15 g of relatively pure white prisms, m.p. 143°-145°; yield 54%. The mother liquor was concentrated to produce more crystals.

Provenance & Evidence