反应详情

To a solution of 2.51 g. of N-(β,β,β-trichloroethoxycarbonyl)thiourea and 2.66 g. of ethyl α-acetamido-β-oxo-γ-bromobutyrate in 50 ml. of ethanol is added 1.8 g. of N,N-dimethylaniline. The mixture is stirred for 24 hours at room temperature, and condensed under reduced pressure. The residue is dissolved in 30 ml. chloroform and the solution is washed with 3N--HCl, water, and dried. The solid matter which is obtained by removal of chloroform is purified by silica gel chromatography to give ethyl α-acetamido-2-(β,β,β-trichloroethoxycarbonylamino)thiazol-4-ylacetate. 1.43 g.

1. customcondensed under reduced pressure
2. dissolutionThe residue is dissolved in 30 ml
3. washchloroform and the solution is washed with 3N
4. dry with materialHCl, water, and dried
5. customThe solid matter which is obtained by removal of chloroform
6. customis purified by silica gel chromatography