HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 4'-Hydroxyacetophenone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Phenol | HCID 996 | — |
| Reactant | Hydrofluoric Acid | HCID 14917 | — |
| Product | 4'-Hydroxyacetophenone | HCID 7469 | 40% |
Reaction Steps
Simons et al, Journal of the American Chemical Society, 61, 1795 and 1796 (1939) teach the acylation of aromatic compounds using hydrogen fluoride as a condensing agent and in Table 1 on page 1796 show the acetylation of phenol with acetic acid to produce p-hydroxyacetophenone (4-HAP) in 40% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04668826 |
| Source dataset | uspto-grants-1987_05 |
| ORD ID | ord-a935d406d3714269818c2d222a26ad10 |
| Source note | uspto-grants-1987_05 |