Thiophosgene → HCID 13563672, compound

Participants

Reaction Steps

To 50 ml of chloroform were dissolved 11.5 g of 4-bromo-3-tert-butylphenol and 6.5 g of thiophosgene, and 60 ml of 1-N sodium hydroxide aqueous solution were added dropwise thereto with stirring at room temperature. After completion of this dropwise addition, the mixture was subjected to stirring over a period of 3 hours at room temperature. From the reaction mixture was separated chloroform layer, which was thereafter dried over anhydrous calcium chloride and then chloroform was distilled off therefrom. The residue was purified through a column chromatography (employing silica gel as carrier and hexane as developing solvent) to give 10.3 g of O-4-bromo-3-tert-butylphenyl chlorothioformate.

Provenance & Evidence