反应详情

Heat 12.5 gm of ethyl (diethoxyphosphino)acetate with 16.9 gm of N-(4-bromobutyl)phthalimide in a melt at 180° for 5 hours under a nitrogen atmosphere. After cooling, chromatograph the mixture on a silica gel column, eluting with a gradient of 1% to 2% CH3OH in EtOAc. Isolate the major product by vacuum evaporation of the solvent from the combined fractions to obtain the title compound. Rf (silica gel; EtOAc:CH3OH, 99:1)=0.40.

1. temperatureAfter cooling
2. washchromatograph the mixture on a silica gel column, eluting with a gradient of 1% to 2% CH3OH in EtOAc
3. customIsolate the major product
4. customby vacuum evaporation of the solvent from the combined fractions