HCID 10378747, compound → HCID 10265374, compound

HRID 979781Notes

Reaction equation

HRID 979781 reaction equation
[CH3:1][N:2]1[CH2:15][C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C@@H:8]2[C@@H:3]1[CH2:4][C@H:5]1[CH2:21][NH:20][C:19]3[C:6]1=[C:7]2[CH:16]=[CH:17][CH:18]=3>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:1][N:2]1[CH2:15][C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C@@H:8]2[C@@H:3]1[CH2:4][C:5]1[C:6]3[C:19]([NH:20][CH:21]=1)=[CH:18][CH:17]=[CH:16][C:7]=32

Participants

4

Reactant 1

HCID 10378747HCID 10378747, compound

Product 1

HCID 10265374HCID 10265374, compound

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

2 g of (5aR*,6aS*,12bS*)-4,5,5a,6,6a,7,8,12b-octahydro-7-methylindolo[4,3-ab]phenanthridine are dissolved in 250 ml of methylene chloride. 20 g of actively precipitated manganese dioxide are subsequently suspended in the solution, and the suspension obtained is stirred at room temperature until thin-layer chromatography reveals no more educt. The reaction solution is then filtered over diatomaceous earth, concentrated and the resultant oil crystallised from methylene chloride. The crystalline title compound is obtained. It melts at 215°.

Workup

  1. customthe suspension obtained
  2. filtrationThe reaction solution is then filtered over diatomaceous earth
  3. concentrationconcentrated
  4. customthe resultant oil crystallised from methylene chloride

Sources & evidence

ORD record
ord-82405d3bcff84f9d8b4e34330656a99d
Source dataset
uspto-grants-1987_01
Patent number
US04634708

Reaction notes

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