Bromosuccinimide → HCID 13491950, compound

Participants

Reaction Steps

4 g of trans-4,6,6a,7,8,12b-hexahydro-7-methylindolo[4,3-ab]phenanthridine are suspended in 300 ml of chloroform, and the stirred suspension is heated to reflux temperature. A solution of 2.7 g of bromosuccinimide in 100 ml of chloroform is quickly added, and the clear reaction solution is then refluxed for a further hour. The cooled reaction solution is extracted with 1n aqueous sodium carbonate solution, the organic phases dried, concentrated and the evaporation residue chromatographed on silica gel with methylene chloride/methanol=95/5 (methylene chloride 10% saturated with NH3). The title compound is obtained. Its bis[base]fumarate is cryst allised from methanol (m.p. 235°-237°).

Provenance & Evidence