反应详情

温度

0 °C

6-Acetamido-tetralone (15 g) was added in small portions to a cold solution of nitric acid (46 ml) at -30° C. After the addition was complete (2-3 hours), the reaction mixture was stirred at the same temperature for 1 hour, warmed to 0° C. and stirred for 4 hours. The reaction was poured on ice, basified with aqueous sodium hydroxide and extracted with ethyl acetate several times. The organic layer was separated, dried and evaporated. The desired 5-nitro-isomer was separated using flash chromatography (ethyl acetate-methylene chloride) to afford 8.73 g (48%).

1. additionAfter the addition
2. custom(2-3 hours)
3. stirringstirred for 4 hours
4. additionThe reaction was poured on ice
5. extractionextracted with ethyl acetate several times
6. customThe organic layer was separated
7. customdried
8. customevaporated
9. customThe desired 5-nitro-isomer was separated
10. customto afford 8.73 g (48%)