Acetic Anhydride → HCID 53649372, compound

Participants

Reaction Steps

The product from Example 101 (18.05 g) was dissolved in ethyl acetate (1 L) and subjected to hydrogenation with 20% Pd/C (dry) in the presence of acetic anhydride (15 ml). The reaction mixture was filtered, and the solvent was evaporated. The residue was dissolved in ethanol (250 ml) and a catalytic amount of sulfuric acid (5 drops) was added. The resulting solution was hydrogenated at room temperature overnight. The catalyst was filtered and the filtrate was washed with 5% sodium bicarbonate dried and the solvent was evaporated to afford the desired compound in 90% yield.

Provenance & Evidence