Oxalyl chloride → HCID 86741186, compound

Participants

Reaction Conditions

Reaction Steps

The product from Example 115 (2.7 g) was dissolved in benzene (25 ml) and oxalyl chloride (2.6 ml) was added. The resulting solution was heated at 50° C. for 30 minutes, then the solvent was evaporated to dryness. The residue was dissolved in methylene chloride (30 ml), cooled to 0° C., and aluminum chloride (4 g) was added. The reaction mixture was stirred at 0° C. for 1 hour then quenched with ice and hydrochloric acid then extracted with methylene chloride. The organic layer was separated, washed with brine, dried and evaporated in vacuo affording the desired product in 50% yield.

Provenance & Evidence