HCID 20222962, compound → N-(5,6,7,8-Tetrahydro-4-methyl-5-oxo-2-naphthalenyl)acetamide

Participants

Reaction Conditions

Reaction Steps

The product from Example 129 (3 g) was treated with a solution of trimethylsilyl polyphosphate (PPSE) (50 ml in o-dichlorobenzene) at 100° C. for 10 minutes. The reaction was cooled to 0° C., quenched with 2NHCl and extracted with methylene chloride. The organic layer was separated, dried and evaporated to one-half the volume and purified on a small bed of silica gel. The desired tetralone was obtained in 40% yield. m.p.

Provenance & Evidence