反应详情

6.1 g of 5,7-dihydro-2-mercapto-5,5,7,7-tetramethylindeno[5,6-d]imidazol-6(1H)-one were suspended in 100 ml of alcohol and treated while cooling with ice with 5.2 g of 2-chloromethyl-4-ethoxy-5-methylpyridine hydrochloride. Thereafter, a solution of 1.9 g of sodium hydroxide in 50 ml of water was added dropwise thereto, the mixture was left to boil at reflux overnight and subsequently evaporated to dryness in vacuo. The residue was dissolved in 300 ml of methylene chloride. The solution was washed firstly with 200 ml of 1.5N sodium hydroxide solution and then with 3×200 ml of water, dried over sodium sulfate and evaporated in vacuo. The product was purified on 120 g of silica gel with ethyl acetate/methylene chloride (1:1) as the elution agent. Crystallization from methylene chloride/petroleum ether gave 2-[[(4-ethoxy-5-methyl-2-pyridyl)methyl]thio]-5,7-dihydro-5,5,7,7-tetramethylindeno[5,6-d]imidazol-6(1H)-one of melting point 187°-189°.

1. additiontreated
2. waitthe mixture was left
3. temperatureat reflux overnight
4. customsubsequently evaporated to dryness in vacuo
5. dissolutionThe residue was dissolved in 300 ml of methylene chloride
6. washThe solution was washed firstly with 200 ml of 1.5N sodium hydroxide solution
7. dry with materialwith 3×200 ml of water, dried over sodium sulfate
8. customevaporated in vacuo
9. customThe product was purified on 120 g of silica gel with ethyl acetate/methylene chloride (1:1) as the elution agent
10. customCrystallization from methylene chloride/petroleum ether