Sodium Hydroxide → 1-(4-Aminophenyl)imidazolidin-2-one

HRID 979898Notes

Reaction equation

HRID 979898 reaction equation
C([NH:4][C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:15][CH2:14][NH:13][C:12]2=[O:16])=[CH:7][CH:6]=1)(=O)C.[OH-].[Na+]>O>[NH2:4][C:5]1[CH:6]=[CH:7][C:8]([N:11]2[CH2:15][CH2:14][NH:13][C:12]2=[O:16])=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13755487N-[4-(2-Oxoimidazolidin-1-yl)phenyl]acetamide

Product 1

HCID 137554911-(4-Aminophenyl)imidazolidin-2-one

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 10 g of 1-(p-acetamidophenyl)-2-imidazolidinone (see Example 1), 10 g of sodium hydroxide and 100 ml of water is heated under reflux for four hours. The product that crystallizes on cooling is collected and recrystallized from ethanol to yield 1-(4-aminophenyl)-2-imidazolidinone, m.p. 170°-2°.

Workup

  1. temperatureis heated
  2. temperatureunder reflux for four hours
  3. customThe product that crystallizes
  4. temperatureon cooling
  5. customis collected
  6. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-e1190468bf6141c5af23737c7018ae53
Source dataset
uspto-grants-1987_01
Patent number
US04634713

Reaction notes

Loading…