HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 979911Generated: October 30, 2026
Hydrogen Bromide → HCID 13588067, compound
https://huagongshe.com/reaction/979911
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | HCID 13587988 | HCID 13587988 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-Piperidinecarboxylic acid, 4-(1H-benzimidazol-2-ylamino)-, ethyl ester | HCID 3018455 | — |
| Product | HCID 13588067 | HCID 13588067 | 93.2% |
Reaction Steps
A mixture of 30 parts of ethyl 4-[[1-[(2-pyridinyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinecarboxylate and 300 parts of a hydrobromic acid solution 48% in water was stirred and heated for 3 hours at 80° C. The reaction mixture was evaporated and the residue was crystallized from methanol, yielding 41 parts (93.2%) of N-(4-piperidinyl)-1-[(2-pyridinyl)methyl]-1H-benzimidazol-2-amine trihydrobromide; mp. 295.9° C. (66).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04634704 |
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| Source dataset | uspto-grants-1987_01 |
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| ORD ID | ord-0676026551c345ee8f2760093c13458e |
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| Source note | uspto-grants-1987_01 |
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