Hydrogen Bromide → HCID 86741196, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 33 parts of ethyl [2-[4-[[1-[(2-bromo-4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinyl ]ethyl]carbamate and 750 parts of a hydrobromic acid solution 48% in water was stirred overnight at 80° C. The reaction mixture was evaporated. The residue was crystallized from ethanol. The product was filtered off and dried, yielding 22.5 parts (65%) of N-[1-(2-aminoethyl)-4-piperidinyl]-1-[(2-bromo-4-fluorophenyl)methyl]-1H-benzimidazol-2-amine trihydrobromide.monohydrate; mp. 224.7° C. (164).

Provenance & Evidence