2-Methoxyethanol → HCID 86741197, compound

Participants

Reaction Steps

A mixture of 24 parts of ethyl [2-[4-[[1-[(4-nitrophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinyl]-ethyl]carbamate, 1 part of a solution of thiophene in methanol 4% and 250 parts of 2-methoxyethanol was hydrogenated at normal pressure and at 50° C. with 3 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated, yielding 22.5 parts (100%) of ethyl [2-[4-[[1-[(4-aminophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinyl]ethyl]carbamate as a residue (170).

Provenance & Evidence