Hydrogen Bromide → HCID 20222896, compound

Participants

Reaction Steps

To a stirred mixture of 37.5 parts of 1-[4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinyl]-3-pentanone dihydrobromide and 500 parts of acetic acid was added a hydrobromic acid solution in glacial acetic acid. Then there were added slowly dropwise 10.5 parts of bromine. Upon completion, stirring was continued overnight at room temperature. The reaction mixture was evaporated and the residue was suspended in 2-propanone. The product was filtered off and dried, yielding 37.5 parts (89%) of 4-bromo-1-[4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinyl]-3-pentanone dihydrobromide (183).

Provenance & Evidence