Sodium Carbonate → HCID 14518102, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred mixture of 5.3 parts of cyanogen bromide, 106. parts of anhydrous sodium carbonate and 45 parts of tetrahydrofuran was added dropwise a solution of 18.35 parts of N-[1-(2-aminoethyl)-4-piperidinyl]-1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-amine in tetrahydrofuran at a temperature between -10° C. and -20° C. Upon completion, stirring was continued for 2 hours at -10° C. After heating to 0° C., the whole was filtered and the filtrate was evaporated, yielding 19 parts (100%) of [2[4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinyl]ethyl]cyanimide as a residue (187).

Provenance & Evidence