Benzene → HCID 20222923, compound

Participants

Reaction Steps

A mixture of 57 parts of 1-ethyl-1,4-dihydro-5H-tetrazol-5one, 69 parts of 1,2-dibromoethane, 564 parts of silver carbonate and 900 parts of benzene was stirred and refluxed over weekend using a water separator (in the darkness). The whole was filtered off over Hyflo while hot, washed with trichloromethane and the filtrate was evaporated to dry. The residue was purified by column chromatography over silica gel using trichloromethane as eluent. The second fraction was collected and the eluent was evaporated, yielding 22.3 parts (40%) of 5-(2-bromoethoxy)-1-ethyl-1H-tetrazole (200).

Provenance & Evidence