Hydrochloric Acid → HCID 13769726, compound

Participants

Reaction Steps

A mixture of 12.5 parts of N-(2,2-dimethoxyethyl)-N'-[2-[4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinyl]ethyl]guanidine monohydroiodide and 100 parts of a hydrochloric acid solution 10% was stirred and refluxed for 1 hour. The reaction mixture was poured onto crushed ice. The whole was treated with a sodium hydroxide solution. The product was extracted with dichloromethane. The extract was dried, filtered and evaporated. The solid residue was crystallized from 4-methyl-2-pentanone. The product was filtered off and dried, yielding 2.3 parts (26%) of 1-[(4-fluorophenyl)methyl]-N-[1-[2-(1H-imidazol-2-ylamino)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine; mp. 226.5° C. (compound 79).

Provenance & Evidence