Sulfur → HCID 13769707, compound

Participants

Reaction Steps

A mixture of 40 parts of N-[2-[[(3,4-dichlorophenyl)methyl]amino]phenyl]-N'-[2-[4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinyl]ethyl]thiourea, 60 parts of mercury(II)oxide, 0.1 parts of sulfur and 400 parts of ethanol was stirred and refluxed overnight. The reaction mixture was filtered over Hyflo and the filtrate was evaporated. The residue was crystallized from ethanol. The product was filtered off and dried, yielding 17 parts (45%) of 1-[(3,4-dichlorophenyl)methyl]-N-[2-[4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]1-piperidinyl]ethyl]-1H-benzimidazol-2-amine; mp. 113.2° C. (compound 83).

Provenance & Evidence