Chloroacetone → HCID 20222894, compound

Participants

Reaction Steps

A mixture of 1.3 parts of 1-chloro-2-propanone, 5 parts of N-[2-[4-[[1-(2-furanylmethyl)-1H-benzimidazol-2-yl]amino]-1-piperidinyl]ethyl]thiourea, 3 parts of potassium carbonate and 68 parts of N,N-dimethylacetamide was stirred overnight at room temperature. Water was added and the product was extracted with 4-methyl-2-pentanone. The extract was dried, filtered and evaporated. The oily residue was purified by column chromatography over silica gel using a mixture of trichloromethane and methanol (95:5 by volume) as eluent. The pure fractions were collected and the eluent was evaporated. The residue was converted into the hydrochloride salt in 2-propanol. The salt was filtered off and dried overnight in vacuo at 100° C., yielding 3.8 parts of 1-(2-furanylmethyl)-N-[1-[2-[(4-methyl-2-thiazolyl)amino]ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine trihydrochloride monohydrate; mp. 238.5° C. (compound 88).

Provenance & Evidence