HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-[(1-Carboxy-3-phenylpropyl)-alpha-azaglycyl]-4(R)-carboxy-2-(2-hydroxyphenyl)thiazolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-[N-(1-Carboxy-3-phenylpropyl)-alpha-azaglycinyl]-4(R)carboethoxy-2-(2-hydroxyphenyl)thiazolidine | HCID 18606071 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | N-[(1-Carboxy-3-phenylpropyl)-alpha-azaglycyl]-4(R)-carboxy-2-(2-hydroxyphenyl)thiazolidine | HCID 18606061 | — |
Reaction Steps
The above diester (Example 50) can be dissolved in aqueous sodium hydroxide (2N; 5 ml) and stirred for 1 hr. The resulting solution can be acidified with dilute hydrochloric acid and the product (59) isolated by ion-exchange chromatography on DOWEX 50W-X4 resin.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04634715 |
| Source dataset | uspto-grants-1987_01 |
| ORD ID | ord-171a68dc4a2d4d51ac6b340f4daafcaa |
| Source note | uspto-grants-1987_01 |