Benzoyl chloride → HCID 13335994, compound

Participants

Reaction Steps

A 23.8 g (0.165 mole) quantity of sodium benzoate was added with stirring to a mixture of 12.8 g (0.05 mole) of ethyl 5-chloro-3-propionylsalicylate and 21.1 g (0.15 mole) of benzoyl chloride. The resulting mixture was heated at 180° to 190° C. for 8 hours to undergo reaction. The reaction mixture was cooled and 100 ml of a 5% aqueous solution of sodium carbonate was added. The mixture was stirred to precipitate solids. The solids were recrystallized from alcohol, giving 15.3 g (89.5%) of white crystals, M.P. 127.0° to 128.2° C. Table 1 below shows the results of chemical analysis.

Provenance & Evidence