反应详情

A 29.4 g (0.10 mole) quantity of methyl 3-methylflavone-8-carboxylate was added to 200 ml of a solution of 0.5N--KOH in methanol. The mixture was refluxed with heating for 3 hours and the solvent was removed by distillation. To the residue was added 300 ml of water to dissolve the residue in water and the solution was subjected to filtration. The filtrate was neutralized with dilute hydrochloric acid to give 27.3 g (97.5%) of 3-methylflavone-8-carboxylic acid, M.P. 229° to 231.5° C.

1. temperatureThe mixture was refluxed
2. temperaturewith heating for 3 hours
3. customthe solvent was removed by distillation
4. additionTo the residue was added 300 ml of water
5. dissolutionto dissolve the residue in water
6. filtrationthe solution was subjected to filtration