Propanal → 1-(5,6-Dimethylpyrazin-2-yl)propan-1-one

HRID 980074Notes

Reaction equation

HRID 980074 reaction equation
[CH3:1][C:2]1[C:7]([CH3:8])=[N:6][CH:5]=[CH:4][N:3]=1.[CH:9](=[O:12])[CH2:10][CH3:11]>CC(C)=O.CCCCCC>[CH3:1][C:2]1[C:7]([CH3:8])=[N:6][C:5]([C:9](=[O:12])[CH2:10][CH3:11])=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 527PropanalHCID 222012,3-Dimethylpyrazine

Product 1

HCID 5722561-(5,6-Dimethylpyrazin-2-yl)propan-1-oneYield 25%

Reagents, catalysts & solvents 1

HCID 21880519Acetone hexaneSolvent

Procedure

The reaction of 2,3-dimethylpyrazine and freshly distilled propionaldehyde is carried out as described in Example I on the same molar scale. Preparative thick layer chromatography (2000μ silica gel GF, developed in 5% acetone/hexane) of the crude reaction product gives a 25% yield of 1-(2,3-dimethyl-5-pyrazinyl)-1-propanone.

Sources & evidence

ORD record
ord-47c4cbb4ea7941648507d5cfcbe89f15
Source dataset
uspto-grants-1987_01
Patent number
US04635652

Reaction notes

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