Ammonia → 84688-49-3

HRID 980076Notes

Reaction equation

HRID 980076 reaction equation
[CH3:1][CH:2](O)[C:3]#[N:4].N[CH:7]([CH:9](N)[CH3:10])[CH3:8].[NH3:12].[OH2:13]>>[CH3:1][CH:2]1[C:3](=[O:13])[NH:4][CH:9]([CH3:10])[CH:7]([CH3:8])[NH:12]1

Participants

5

Reactant 4

HCID 222AmmoniaHCID 962WaterHCID 6572LactonitrileHCID 1363622,3-Butanediamine

Product 1

HCID 1312504484688-49-3Yield 72%

Conditions

Temperature
25 °C

Procedure

138.5 g (1.95 moles) of acetaldehyde cyanohydrin were added dropwise to a solution of 176 g (2 moles) of 2,3-diaminobutane in 250 ml of water, with cooling at 25° C. The mixture was then heated at the boil for 8 hours, until no more ammonia was split off. The reaction mixture was then distilled under reduced pressure to give 200 g (72% of theory) of 2,5,6-trimethyl-3-oxo-piperazine of boiling point 123° C./0.5 mbar.

Workup

  1. customwas split off
  2. distillationThe reaction mixture was then distilled under reduced pressure

Sources & evidence

ORD record
ord-1f47e5c4f86c4ebfa3dad6257027a204
Source dataset
uspto-grants-1987_01
Patent number
US04636246

Reaction notes

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