Hydrochloric Acid → HCID 13579045, compound

Participants

Reaction Steps

9.6 g (0.07 mol) of zinc chloride are first added to 5 g (0.035 mol) of 6,6-dimethyltetrahydrothiopyran-2,4-dione in 100 ml of pyridine, after which 3.7 g (0.03 mol) of butyryl chloride are added dropwise. When the addition is complete, the mixture is heated to the reflux temperature for 4 hours, and the cooled reaction mixture is poured into 200 ml of semi-concentrated hydrochloric acid, the mixture is extracted several times with dichloromethane, the combined organic phases are dried over magnesium sulphate, and the solvent is removed in vacuo. 2.9 g (36.6% of theory) of 6,6-dimethyl-3-butyryltetrahydrothiopyran-2,4-dione are obtained as an oil.

Provenance & Evidence