Dichloromethane → 2,5-Diphenyl-3(2,3-dibromopropionyl)oxazolidine

HRID 980092ノート

反応式

HRID 980092 の反応式
[C:1]1([CH:7]2[NH:11][CH2:10][CH:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[O:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(Cl)Cl.[Br:21][CH:22]([CH2:26][Br:27])[C:23](Cl)=[O:24]>C(N(CC)CC)C>[C:1]1([CH:7]2[N:11]([C:23](=[O:24])[CH:22]([Br:21])[CH2:26][Br:27])[CH2:10][CH:9]([C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=3)[O:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 6344DichloromethaneHCID 867902,3-Dibromopropanoyl chlorideHCID 20221975HCID 20221975、化合物

生成物 1

HCID 133634792,5-Diphenyl-3(2,3-dibromopropionyl)oxazolidine

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

Four and five tenths (4.5) grams of 2,5-diphenyl oxazolidine was dissolved in 50 ml. of methylene chloride and 5 g. of 2,3-dibromopropionyl chloride was added and the mixture stirred in an ice bath, while 2.1 g. of triethylamine was added dropwise. After standing for about 30 minutes, the mixture was washed with water, separated and dried over magnesium sulfate and stripped under vacuum. There was obtained a yield of 7.1 g. of an oil, the title compound, ND30 =1.5734.

後処理

  1. washthe mixture was washed with water
  2. customseparated
  3. dry with materialdried over magnesium sulfate
  4. customThere was obtained a yield of 7.1 g

出典と根拠

ORDレコード
ord-84d4f5f45d5543b495c2a438294b9d78
出典データセット
uspto-grants-1987_01
特許番号
US04636244

反応ノート

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